Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-hydroxy-trans-2-nonenal | - |
Rattus norvegicus | |
sorbinil | AR inhibitor, prevents hyperproliferation of aortic smooth muscle cells | Rattus norvegicus | |
Tolrestat | AR inhibitor, prevents hyperproliferation of aortic smooth muscle cells, cell cycle progression in the presence of high glucose was blocked by tolrestat | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | the enzyme regulates high-glucose-induced growth and contributes to diabetic hyperproliferation of vascular smooth muscle cells, inhibition of the enzyme also increases vascular oxidative stress, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aorta | - |
Rattus norvegicus | - |
smooth muscle | vascular cell | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme regulates high-glucose-induced growth and contributes to diabetic hyperproliferation of vascular smooth muscle cells, inhibition of the enzyme also increases vascular oxidative stress, overview | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aldose reductase | - |
Rattus norvegicus |